Shin'ichi Takeda Selected Research

Muscular Dystrophies (Muscular Dystrophy)

11/2021	Development of outcome measures according to dystrophic phenotypes in canine X-linked muscular dystrophy in Japan.
10/2021	Mesenchymal stem cells derived from human induced pluripotent stem cells improve the engraftment of myogenic cells by secreting urokinase-type plasminogen activator receptor (uPAR).
1/2021	Immortalized Canine Dystrophic Myoblast Cell Lines for Development of Peptide-Conjugated Splice-Switching Oligonucleotides.
1/2019	Characterization of a novel microRNA, miR-188, elevated in serum of muscular dystrophy dog model.
1/2019	Efficacy of Multi-exon Skipping Treatment in Duchenne Muscular Dystrophy Dog Model Neonates.
1/2018	Exon Skipping Using Antisense Oligonucleotides for Laminin-Alpha2-Deficient Muscular Dystrophy.
1/2018	In Vitro Multiexon Skipping by Antisense PMOs in Dystrophic Dog and Exon 7-Deleted DMD Patient.
1/2018	Premyogenic progenitors derived from human pluripotent stem cells expand in floating culture and differentiate into transplantable myogenic progenitors.
10/2017	Treatment with the anti-IL-6 receptor antibody attenuates muscular dystrophy via promoting skeletal muscle regeneration in dystrophin-/utrophin-deficient mice.
1/2017	Mitochondria mediate cell membrane repair and contribute to Duchenne muscular dystrophy.

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Shin'ichi Takeda Research Topics

Disease

84	Duchenne Muscular Dystrophy (Muscular Dystrophy, Becker) 01/2022 - 03/2002
47	Muscular Dystrophies (Muscular Dystrophy) 11/2021 - 03/2002
15	Muscular Diseases (Myopathy) 01/2022 - 03/2004
8	Inborn Genetic Diseases (Disease, Hereditary) 01/2021 - 11/2003
7	Inflammation (Inflammations) 01/2021 - 07/2003
7	Fibrosis (Cirrhosis) 01/2021 - 06/2005
7	Muscular Atrophy (Muscle Atrophy) 01/2019 - 09/2007
5	Necrosis 01/2021 - 11/2009
4	Hypertrophy 09/2018 - 09/2002
4	Atrophy 01/2013 - 03/2004
3	Ehlers-Danlos Syndrome (Syndrome, Ehlers-Danlos) 12/2021 - 01/2018
3	Muscle Weakness 01/2021 - 01/2016
3	Neuromuscular Diseases (Neuromuscular Disease) 07/2019 - 09/2014
3	Limb-Girdle Muscular Dystrophies (Limb-Girdle Muscular Dystrophy) 02/2009 - 03/2005
2	Wasting Syndrome (Wasting Disease) 01/2021 - 01/2016
2	Contracture 01/2021 - 11/2015
2	Disease Progression 01/2021 - 08/2014
2	Respiratory Insufficiency (Respiratory Failure) 11/2015 - 12/2006
2	Walker-Warburg Syndrome 02/2015 - 10/2011
2	Miyoshi myopathy 10/2006 - 10/2005
1	Intellectual Disability (Idiocy) 01/2022
1	Autism Spectrum Disorder 01/2022
1	Cardiomyopathies (Cardiomyopathy) 01/2021
1	Cognitive Dysfunction 11/2020
1	X-Linked Genetic Diseases 04/2020
1	Drug-Related Side Effects and Adverse Reactions 01/2020
1	Musculoskeletal Diseases (Musculoskeletal Disease) 01/2020
1	Hyperglycemia 01/2019
1	Rhabdomyosarcoma 12/2018
1	Lymphoma (Lymphomas) 01/2018

Drug/Important Bio-Agent (IBA)

66	DystrophinIBA 01/2022 - 03/2002
20	Proteins (Proteins, Gene)FDA Link 12/2020 - 03/2002
11	Antisense OligonucleotidesIBA 12/2018 - 04/2007
10	MorpholinosIBA 03/2019 - 11/2009
7	Messenger RNA (mRNA)IBA 01/2018 - 01/2011
6	CytokinesIBA 01/2021 - 10/2007
5	Biomarkers (Surrogate Marker)IBA 11/2021 - 03/2011
5	UbiquitinIBA 01/2019 - 09/2007
4	Ligases (Synthetase)IBA 01/2018 - 09/2007
4	Dystroglycans (Dystroglycan)IBA 02/2015 - 02/2009
4	Laminin (Merosin)IBA 01/2015 - 08/2004
3	Protein Isoforms (Isoforms)IBA 01/2022 - 11/2011
3	SteroidsIBA 03/2020 - 10/2016
3	MicroRNAs (MicroRNA)IBA 01/2019 - 01/2008
3	Pharmaceutical PreparationsIBA 01/2018 - 01/2016
3	DysferlinIBA 01/2017 - 10/2005
3	Creatine Kinase (Creatine Phosphokinase)IBA 01/2016 - 01/2010
3	OsteopontinIBA 01/2016 - 07/2003
2	Dermatan SulfateIBA 12/2021 - 01/2021
2	MyostatinIBA 01/2021 - 02/2008
2	Nonsense Codon (Nonsense Mutation)IBA 01/2021 - 11/2003
2	3-deazaneplanocinIBA 02/2020 - 01/2019
2	TAS-205IBA 01/2020 - 11/2018
2	Peptides (Polypeptides)IBA 07/2019 - 01/2017
2	Transcription Factors (Transcription Factor)IBA 01/2019 - 09/2007
2	RNA Precursors (Precursor, mRNA)IBA 12/2018 - 01/2018
2	CalciumIBA 09/2018 - 05/2013
2	TOR Serine-Threonine KinasesIBA 09/2018 - 05/2013
2	Prednisolone (Predate)FDA LinkGeneric 01/2018 - 12/2013
2	CollagenIBA 01/2018 - 10/2008
2	Muscle Proteins (Muscle Protein)IBA 01/2018 - 09/2014
2	Reactive Oxygen Species (Oxygen Radicals)IBA 01/2018 - 03/2004
2	Granulocyte Colony-Stimulating Factor (G-CSF)IBA 06/2015 - 04/2015
2	Capsaicin (Zostrix)FDA Link 05/2013 - 01/2013
2	Nitric Oxide Synthase Type I (Neuronal Nitric Oxide Synthase)IBA 01/2013 - 07/2010
2	Collagen Type I (Type I Collagen)IBA 11/2011 - 06/2005
2	Matrix Metalloproteinases (MMPs)IBA 05/2011 - 06/2007
2	Intercellular Signaling Peptides and Proteins (Growth Factors)IBA 09/2009 - 05/2006
2	Insulin (Novolin)FDA Link 09/2009 - 10/2007
2	Sarcoglycans (beta Sarcoglycan)IBA 07/2008 - 03/2005
1	CyclinsIBA 01/2021
1	ChemokinesIBA 01/2021
1	DecorinIBA 01/2021
1	CDN1163IBA 01/2021
1	Telomerase (Telomerase Reverse Transcriptase)IBA 01/2021
1	Tacrolimus (Prograf)FDA LinkGeneric 09/2020
1	Prostaglandin D2IBA 01/2020
1	1,2- diarachidonoyl- glycero- 3- phosphocholineIBA 01/2020
1	prostaglandin R2 D-isomerase (prostaglandin D2 synthase)IBA 01/2020
1	Phospholipids (Phosphatides)FDA LinkGeneric 01/2020
1	GlycogenIBA 03/2019
1	RNA-Binding Proteins (RNA-Binding Protein)IBA 03/2019
1	Ubiquitin-Protein Ligases (Ubiquitin-Protein Ligase)IBA 01/2019
1	OligonucleotidesIBA 12/2018
1	Mitogen-Activated Protein KinasesIBA 09/2018
1	Adenosine Triphosphate (ATP)IBA 09/2018
1	EnzymesIBA 01/2018
1	DNA (Deoxyribonucleic Acid)IBA 01/2018
1	Interleukin-6 (Interleukin 6)IBA 10/2017
1	Myosin Heavy Chains (Myosin Heavy Chain)IBA 10/2017
1	UtrophinIBA 10/2017
1	Complement C5a (Complement 5a)IBA 05/2017
1	NOX-D21IBA 05/2017
1	Arginine (L-Arginine)FDA Link 01/2017

Therapy/Procedure

26	Therapeutics 03/2020 - 05/2002
4	Denervation 01/2013 - 05/2006
3	Cell- and Tissue-Based Therapy (Cell Therapy) 01/2018 - 11/2006
2	Transplantation 10/2021 - 01/2021
1	Cell Transplantation 01/2020
1	Traction 01/2018